In healthy individuals, b-cells counteract sharp increases in blood glucose, such as those caused by a meal, by releasing an initial "spike" of insulin within a few minutes of the glucose challenge. The condition occurs as a result of the body being unable to produce enough of the hormone insulin or use it effectively.
Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: The insulin-producing b-cell is one type of endocrine cell in the islet; other types include alpha cells a-cellswhich produce glucagon, gamma cells g-cellswhich produce pancreatic polypeptide, and delta cells d-cellswhich produce somatostatin.
If, however, safe alternate methods based on this research can be developed for reprogramming cells, then iPS cells may lead to novel, personalized therapies. Encircled is the beta cell that synthesizes and secretes insulin.
Beta-cell neogenesis during prolonged hyperglycemia in rats. Accessed September 15, This section will suggest several envisioned approaches for stem-cell derived diabetes therapies and discuss key considerations that must be addressed for their successful application.
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Given current debate on this issue, the routine clinical application of stem-cell based regenerative therapy for the treatment of diabetes remains a future goal, albeit one with great potential.
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. This approach may facilitate the establishment of human iPS cell lines from patients with specific diseases that could be used as research tools.
Lipsett M, Finegood DT. At present, there is no cure for diabetes. Once isolated from other cells, these differentiated cells could be transplanted into a patient. However, the lack of available appropriate donor tissue and the strenuous regimen of immunosuppresive drugs necessary to keep the body from rejecting the transplanted tissue limit the widespread use of this approach.
Centers for Disease Control and Prevention. Type 2 diabetes, the more common form, is characterized both by insulin resistance, a condition in which various tissues in the body no longer respond properly to insulin action, and by subsequent progressive decline in b-cell function to the point that the cells can no longer produce enough additional insulin to overcome the insulin resistance.
Contingent upon the development of appropriate protocols, stem cells could theoretically be used to treat diabetes through two approaches. As an additional source of information, an extensive discussion of research challenges and strategies for achieving the goal of cell replacement therapy for Type 1 diabetes is presented in Advances and Emerging Opportunities in Type 1 Diabetes Research: The strategy may also have implications for ameliorating type 2 diabetes.
Other Potential Sources of Stem Cells Derived from Adult Cells Furthermore, various reports have also described putative stem cells in the liver, spleen, central nervous system, and bone marrow that can differentiate into insulin-producing cells.Type 1 diabetes is an appropriate candidate disease for stem cell therapy, as the causative damage is localized to a particular cell type.
In theory, stem cells that can differentiate into b-cells in response to molecular signals in the local pancreatic environment could be introduced into the body, where they would migrate to the. Diabetes, or fully named Diabetes Mellitus is when a person has high blood sugar and that is cause by the lack of insulin produced by the pancreas or it is when the cells do not respond to the insulin produced, it is also according to the type of diabetes that the cause may be different from others.
Stem Cell Therapy for Diabetes Essay Words | 5 Pages. Diabetes, or fully named Diabetes Mellitus is when a person has high blood sugar and that is cause by the lack of insulin produced by the pancreas or it is when the cells do not respond to the insulin produced, it is also according to the type of diabetes that the cause may be different.
Stem Cell Therapy for Diabetes Type 1 and Diabetes Type 2. New treatments and advances in research are giving new hope to people affected by Diabetes Type 1. Stem Cell Treatment for Diabetes Type 2 in Swiss Medica Clinic.
Swiss Medica Clinic has developed the Adult Autologous Stem Cell Therapy program to treat a variety of conditions. During stem cell treatment a patient receives – million stem cells. The quantity of restored cells not only covers daily losses, but exceeds them a.
Stem Cell Therapy for Diabetes It has been suggested that stem cell therapy is the answer to treating many patients greatly improving their quality of life. [tags: Multicellular Organisms, Stem Cell Therapy] In this essay, I will explain embryonic stem cells concept, and importance of utilizing it in medical development.